
STUDIES.
SCIENTIFIC RESEARCH
IN FOCUS.

NOA-04-Trial (prospective, randomized phase-3-trial in anaplastic glioma)
NOA-04-Trial (prospective, randomized phase-3-trial in anaplastic glioma)
The NOA-04-study investigated the question of whether chemotherapy can be used instead of radiotherapy in the primary treatment of anaplastic gliomas after surgery. Between October 1999 and February 2005, 318 patients were randomized in 36 German centers. The primary endpoint was the time to treatment failure. Treatment failure is defined as the time to second progression or a point in time before the second progression at which further treatment is not possible.